{"id":159,"date":"2023-09-25T21:52:43","date_gmt":"2023-09-25T21:52:43","guid":{"rendered":"https:\/\/belotero.m3rzd3v.com\/wp\/?page_id=159"},"modified":"2026-04-21T15:11:17","modified_gmt":"2026-04-21T19:11:17","slug":"belotero-clinical-data-moa","status":"publish","type":"page","link":"https:\/\/merzaesthetics-ca.m3rzd3v.com\/fr\/belotero\/hcp\/belotero-clinical-data-moa\/","title":{"rendered":"Clinical Data\/MOA"},"content":{"rendered":"<section class=\"gb-container gb-container-0ef65f5f section-hcp section-hcp--hero\">\n<div class=\"gb-container gb-container-99b85669 grid-container\">\n<div class=\"gb-grid-wrapper gb-grid-wrapper-739e85ee\">\n<div class=\"gb-grid-column gb-grid-column-ee33530c\"><div class=\"gb-container gb-container-ee33530c\">\n\n<h1 class=\"gb-headline gb-headline-c09565bd gb-headline-text\">Product features and clinical data<\/h1>\n\n\n\n<p class=\"gb-headline gb-headline-ae06e9ab gb-headline-text\">Learn more about the characteristics of Belotero Balance (+) that set it apart from other hyaluronic acid (HA) fillers and make it an optimal choice for your patients.<\/p>\n\n<\/div><\/div>\n\n<div class=\"gb-grid-column gb-grid-column-1bc81610\"><div class=\"gb-container gb-container-1bc81610\"><\/div><\/div>\n<\/div>\n<\/div>\n<\/section>\n\n<section class=\"gb-container gb-container-36d48b0a section-hcp section-hcp--body\">\n<div class=\"gb-container gb-container-fc702245 grid-container offset-container image-tag\">\n\n<h2 class=\"gb-headline gb-headline-abe34410 gb-headline-text\">AN HA FILLER DESIGNED TO FLEX<\/h2>\n\n\n\n<p class=\"gb-headline gb-headline-e7103693 gb-headline-text\">Rheologic properties\u2014such as cohesivity, elasticity, and viscosity\u2014are used as a scientific rationale when selecting the appropriate filler for specific clinical applications. Learn more about the clinical significance of these properties, and then understand how the rheologic profile of Belotero Balance (+) contributes to its ability to achieve results with a smooth and natural feel.<sup>1-5<\/sup><\/p>\n\n\n<div class=\"gb-grid-wrapper gb-grid-wrapper-9ae3dc06 grid-padding\">\n<div class=\"gb-grid-column gb-grid-column-a72d91ce\"><div class=\"gb-container gb-container-a72d91ce splotch-element\">\n\n<h3 class=\"gb-headline gb-headline-fab6f2e5 gb-headline-text\">Cohesivity<\/h3>\n\n\n<div class=\"gb-container gb-container-0094d5a6 match\">\n\n<p class=\"gb-headline gb-headline-e242151c gb-headline-text\"><strong>Definition:<\/strong> Capacity of a material to not dissociate, because of the intrinsic affinity of the constituent molecules for each other<sup>1<\/sup> <\/p>\n\n\n\n<p class=\"gb-headline gb-headline-3bcf484f gb-headline-text\"><strong>Clinical significance:<\/strong> Ability to resist heterogeneous distribution after introduction into the tissue<\/p>\n\n<\/div>\n\n\n<a class=\"gb-button gb-button-782c6c75 gb-button-text gb-button-acf94e91\" href=\"#cohesivity\">High Cohesivity<\/a>\n\n<\/div><\/div>\n\n<div class=\"gb-grid-column gb-grid-column-1db7bb6a\"><div class=\"gb-container gb-container-1db7bb6a splotch-element\">\n\n<h3 class=\"gb-headline gb-headline-e0f0acd0 gb-headline-text\">Elasticity<\/h3>\n\n\n<div class=\"gb-container gb-container-9c52d0c2 match\">\n\n<p class=\"gb-headline gb-headline-7d777cb5 gb-headline-text\"><strong>Definition:<\/strong> Ability of a gel to resist deformation when pressure is applied<sup>9<\/sup><\/p>\n\n\n\n<p class=\"gb-headline gb-headline-dfefcbd4 gb-headline-text\"><strong>Clinical significance:<\/strong> Capacity to support tissue<\/p>\n\n<\/div>\n\n\n<a class=\"gb-button gb-button-a7cba8ab gb-button-text gb-button-acf94e91\" href=\"#elasticity\">Low Elasticity<\/a>\n\n<\/div><\/div>\n\n<div class=\"gb-grid-column gb-grid-column-f61b7808\"><div class=\"gb-container gb-container-f61b7808 splotch-element\">\n\n<h3 class=\"gb-headline gb-headline-fd2f5183 gb-headline-text\">Viscosity<\/h3>\n\n\n<div class=\"gb-container gb-container-f3848d17 match\">\n\n<p class=\"gb-headline gb-headline-b30bbe83 gb-headline-text\"><strong>Definition:<\/strong> Ability of a gel (in the fluid phase) to resist shearing forces<sup>1,4,9<\/sup><\/p>\n\n\n\n<p class=\"gb-headline gb-headline-48f844e6 gb-headline-text\"><strong>Clinical significance:<\/strong> Ability to spread and integrate into tissues<\/p>\n\n<\/div>\n\n\n<a class=\"gb-button gb-button-cf9df90f gb-button-text gb-button-acf94e91\" href=\"#viscosity\">Low Viscosity<\/a>\n\n<\/div><\/div>\n<\/div>\n<\/div>\n\n<div class=\"gb-container gb-container-025b5970 grid-container\">\n<div class=\"gb-grid-wrapper gb-grid-wrapper-c5c852b1\">\n<div class=\"gb-grid-column gb-grid-column-624c1d47\"><div class=\"gb-container gb-container-624c1d47\">\n\n<h2 class=\"gb-headline gb-headline-dbf809e7 gb-headline-text\" id=\"formula\">The Belotero Balance (+) formula<\/h2>\n\n\n\n<h3 class=\"gb-headline gb-headline-00ae2014 gb-headline-text\">High cohesivity + balanced elasticity &amp; viscosity<sup>1<\/sup><\/h3>\n\n\n\n<p class=\"has-text-align-left\" style=\"margin-bottom:20px\">These attributes of Belotero Balance (+) give it a soft, spreading quality with a tendency to flow and homogeneously integrate into tissue, as well as the ability to maintain its gel structure when mechanically stressed.<sup>1,3,5<\/sup> This is important for treating etched-in lines, which tend to be present in very mobile and highly visible facial areas with little room for post-injection swelling.<sup>1,4<\/sup><\/p>\n\n<\/div><\/div>\n<\/div>\n<\/div>\n\n<div class=\"gb-container gb-container-41464a30 grid-container\">\n<div class=\"gb-grid-wrapper gb-grid-wrapper-44978b3a\">\n<div class=\"gb-grid-column gb-grid-column-1c77bdaf\"><div class=\"gb-container gb-container-1c77bdaf\">\n\n<h3 class=\"gb-headline gb-headline-9c7f4735 gb-headline-text\" id=\"cohesivity\">Belotero Balance (+) has HIGH cohesivity<\/h3>\n\n\n<div class=\"gb-container gb-container-5fecf99e\">\n\n<h4 class=\"gb-headline gb-headline-ba473a52 gb-headline-text\">In HA fillers, cohesivity is a deciding factor to consider<\/h4>\n\n\n\n<p>Evaluating cohesivity helps you better understand and leverage distribution patterns and clinical behaviors of different HA fillers.<\/p>\n\n\n\n<p>Belotero Balance (+) has an ideal rheologic profile, including high cohesivity, that helps<sup>1,4<\/sup>:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li style=\"font-style:normal;font-weight:300\">Maintain gel integrity<\/li>\n\n\n\n<li style=\"font-style:normal;font-weight:300\">Contribute to tissue support<\/li>\n\n\n\n<li style=\"font-style:normal;font-weight:300\">Inject and spread evenly<\/li>\n<\/ul>\n\n<\/div>\n\n<div class=\"gb-container gb-container-d11c4332\">\n\n<h4 class=\"gb-headline gb-headline-a4bef5b5 gb-headline-text\">Overall, Belotero Balance (+) was found to be the most cohesive among Health Canada Approved HA fillers evaluated with the Gavard-Sundaram Cohesivity scale<sup>10*\u2020<\/sup><\/h4>\n\n\n\n<p>Cohesivity is difficult to measure. The Gavard-Sundaram Cohesivity Scale was developed as a standardized protocol for measuring HA cohesivity and evaluating HA fillers. To measure cohesivity levels, each filler was<sup>10<\/sup>:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li style=\"font-style:normal;font-weight:300\">Dyed blue<\/li>\n\n\n\n<li style=\"font-style:normal;font-weight:300\">Injected into a beaker of water<\/li>\n\n\n\n<li style=\"font-style:normal;font-weight:300\">Evaluated at various time intervals for its ability not to dissociate (ie, to maintain its shape in the water)<\/li>\n<\/ul>\n\n\n\n<p class=\"small\"><sup>*<\/sup> Belotero Balance(+) was compared to Juv\u00e9derm Ultra, Juv\u00e9derm Ultra Plus, Juv\u00e9derm Voluma, Restylane, Restylane Sub Q.<br><sup>\u2020<\/sup> Clinical implications of in vitro data comparison have not been studied.<\/p>\n\n<\/div>\n\n<div class=\"gb-container gb-container-05c2d1ee\">\n<div class=\"gb-container gb-container-b94ccbf9\">\n\n<div data-wp-context=\"{ &quot;autoclose&quot;: false, &quot;accordionItems&quot;: [] }\" data-wp-interactive=\"core\/accordion\" role=\"group\" class=\"wp-block-accordion is-layout-flow wp-block-accordion-is-layout-flow\">\n<div data-wp-class--is-open=\"state.isOpen\" data-wp-context=\"{ &quot;id&quot;: &quot;accordion-item-1&quot;, &quot;openByDefault&quot;: false }\" data-wp-init=\"callbacks.initAccordionItems\" data-wp-on-window--hashchange=\"callbacks.hashChange\" class=\"wp-block-accordion-item is-layout-flow wp-block-accordion-item-is-layout-flow\">\n<h3 class=\"wp-block-accordion-heading has-small-font-size\"><button aria-expanded=\"false\" aria-controls=\"accordion-item-1-panel\" data-wp-bind--aria-expanded=\"state.isOpen\" data-wp-on--click=\"actions.toggle\" data-wp-on--keydown=\"actions.handleKeyDown\" id=\"accordion-item-1\" type=\"button\" class=\"wp-block-accordion-heading__toggle\"><span class=\"wp-block-accordion-heading__toggle-title\">Expand for study design<\/span><span class=\"wp-block-accordion-heading__toggle-icon\" aria-hidden=\"true\">+<\/span><\/button><\/h3>\n\n\n\n<div inert aria-labelledby=\"accordion-item-1\" data-wp-bind--inert=\"!state.isOpen\" id=\"accordion-item-1-panel\" role=\"region\" class=\"wp-block-accordion-panel is-layout-flow wp-block-accordion-panel-is-layout-flow\"><div class=\"gb-container gb-container-20aea94a\">\n\n<p><strong>Standardized Photographic Cohesivity Scale<\/strong><br>To create this scale, the cohesivity assay was performed on 10 types of HA fillers, during which a total of 90 photographs (3 assays x 3 time points x 10 specimens) were taken and reviewed. Through this process, 5 principal patterns of gel behavior were identified and then used to develop a 5-point visual reference scale.<sup>10<\/sup><\/p>\n\n\n\n<p><strong>Validation of the Cohesivity Assay<\/strong><br>A panel of 6 plastic surgeons and dermatologists served as raters to determine the reliability, sensitivity, and repeatability of the cohesivity assay.<sup>10<\/sup><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li style=\"font-style:normal;font-weight:300\">Panelists had no prior training or exposure to any assay images<\/li>\n\n\n\n<li style=\"font-style:normal;font-weight:300\">Reliability, sensitivity, and repeatability of the cohesivity assay were determined by viewing 60 photos (2 assays x 3 time points x 10 specimens)<\/li>\n\n\n\n<li><strong>Good inter-rater consistency and repeatability were observed for most images<\/strong><\/li>\n<\/ul>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th><strong>Cohesivity score<\/strong><\/th><th><strong>Kappa<\/strong><\/th><th><strong>SE<\/strong><\/th><th><strong>95% CI<\/strong><\/th><th><strong><em>P<\/em><\/strong><\/th><\/tr><\/thead><tbody><tr><td>1<\/td><td>0.72126<\/td><td>0.033333<\/td><td>0.65593-0.7866<\/td><td>&lt;0.0001<\/td><\/tr><tr><td>2<\/td><td>0.27885<\/td><td>0.033333<\/td><td>0.21351-0.34418<\/td><td>&lt;0.0001<\/td><\/tr><tr><td>3<\/td><td>0.65666<\/td><td>0.033333<\/td><td>0.59133-0.722<\/td><td>&lt;0.0001<\/td><\/tr><tr><td>4<\/td><td>0.61325<\/td><td>0.033333<\/td><td>0.54791-0.67858<\/td><td>&lt;0.0001<\/td><\/tr><tr><td>5<\/td><td>0.73034<\/td><td>0.033333<\/td><td>0.665-0.79567<\/td><td>&lt;0.0001<\/td><\/tr><tr><td>Overall weighted kappa<\/td><td>0.62798<\/td><td>0.017488<\/td><td>0.5937-0.66225<\/td><td>&lt;0.0001<\/td><\/tr><tr><td>Kendall coefficient of concordance<\/td><td>0.94752<\/td><td><\/td><td><\/td><td>&lt;0.0001<\/td><\/tr><\/tbody><\/table><figcaption class=\"wp-element-caption\">CI=confidence interval; SE=standard error.<\/figcaption><\/figure>\n\n<\/div><\/div>\n<\/div>\n<\/div>\n\n<\/div>\n<\/div>\n\n\n<p class=\"gb-headline gb-headline-0b89fab1 gb-headline-text\">Compare the cohesivity of different HA fillers<sup>10<\/sup><\/p>\n\n\n\n<div class=\"d-lg-flex bs-5Y9K1\" id=\"bs-tabs-5Y9K1\"><ul class=\"nav nav-tabs flex-lg-column\" role=\"tablist\"><li class=\"nav-item\" role=\"presentation\"><a href=\"#\" id=\"bs-tabs-5Y9K1-0-tab\" data-bs-target=\"#bs-tabs-5Y9K1-0-pane\" aria-controls=\"bs-tabs-5Y9K1-0-pane\" aria-selected=\" true\" data-bs-toggle=\"tab\" type=\"button\" role=\"tab\" class=\"nav-link active\">Juvederm\u00ae<\/a><\/li><li class=\"nav-item\" role=\"presentation\"><a href=\"#\" id=\"bs-tabs-5Y9K1-1-tab\" data-bs-target=\"#bs-tabs-5Y9K1-1-pane\" aria-controls=\"bs-tabs-5Y9K1-1-pane\" aria-selected=\"false\" data-bs-toggle=\"tab\" type=\"button\" role=\"tab\" class=\"nav-link\">Juv\u00e9derm\u00ae Ultra Plus XC<\/a><\/li><li class=\"nav-item\" role=\"presentation\"><a href=\"#\" id=\"bs-tabs-5Y9K1-2-tab\" data-bs-target=\"#bs-tabs-5Y9K1-2-pane\" aria-controls=\"bs-tabs-5Y9K1-2-pane\" aria-selected=\"false\" data-bs-toggle=\"tab\" type=\"button\" role=\"tab\" class=\"nav-link\">Juv\u00e9derm\u00ae Voluma\u00ae XC<\/a><\/li><li class=\"nav-item\" role=\"presentation\"><a href=\"#\" id=\"bs-tabs-5Y9K1-3-tab\" data-bs-target=\"#bs-tabs-5Y9K1-3-pane\" aria-controls=\"bs-tabs-5Y9K1-3-pane\" aria-selected=\"false\" data-bs-toggle=\"tab\" type=\"button\" role=\"tab\" class=\"nav-link\">Restylane\u00ae<\/a><\/li><\/ul><div class=\"tab-content\">\n<div class=\"tab-pane fade show active\" id=\"bs-tabs-5Y9K1-0-pane\" role=\"tabpanel\" aria-labelledby=\"bs-tabs-5Y9K1-0-tab\"><div class=\"gb-container gb-container-3a482787\" id=\"tab-panel-1\">\n<div class=\"gb-grid-wrapper gb-grid-wrapper-4910d123\">\n<div class=\"gb-grid-column gb-grid-column-178bd1a7\"><div class=\"gb-container gb-container-178bd1a7\">\n\n<p class=\"gb-headline gb-headline-ceed5b47 gb-headline-text\">Belotero Balance\u00ae<\/p>\n\n\n\n<p>Cohesive polydensified matrix<br>Cohesivity score*: 5.0<br>(fully cohesive)<\/p>\n\n<\/div><\/div>\n\n<div class=\"gb-grid-column gb-grid-column-6fd9682e\"><div class=\"gb-container gb-container-6fd9682e\">\n\n<p class=\"gb-headline gb-headline-af304b55 gb-headline-text\">Juv\u00e9derm\u00ae Ultra XC<\/p>\n\n\n\n<p>Hylacross\u2122<br>Cohesivity score*: 4.1 at 95 secs<br>(mostly cohesive)<\/p>\n\n<\/div><\/div>\n<\/div>\n\n\n<figure class=\"wp-block-video bs-20zqPg\"><video height=\"720\" style=\"aspect-ratio: 1280 \/ 720;\" width=\"1280\" controls poster=\"https:\/\/www.belotero.com\/app\/uploads\/2023\/10\/CompareVideo-FPO.jpg\" src=\"https:\/\/www.belotero.com\/app\/uploads\/2023\/11\/Belotero-JuvedermUltraXC.mp4\"><\/video><\/figure>\n\n<\/div><\/div>\n\n\n\n<div class=\"tab-pane fade\" id=\"bs-tabs-5Y9K1-1-pane\" role=\"tabpanel\" aria-labelledby=\"bs-tabs-5Y9K1-1-tab\"><div class=\"gb-container gb-container-3a482787\" id=\"tab-panel-1\">\n<div class=\"gb-grid-wrapper gb-grid-wrapper-4910d123\">\n<div class=\"gb-grid-column gb-grid-column-178bd1a7\"><div class=\"gb-container gb-container-178bd1a7\">\n\n<p class=\"gb-headline gb-headline-ceed5b47 gb-headline-text\">Belotero Balance\u00ae<\/p>\n\n\n\n<p>Cohesive polydensified matrix<br>Cohesivity score*: 5.0<br>(fully cohesive)<\/p>\n\n<\/div><\/div>\n\n<div class=\"gb-grid-column gb-grid-column-6fd9682e\"><div class=\"gb-container gb-container-6fd9682e\">\n\n<p class=\"gb-headline gb-headline-af304b55 gb-headline-text\">Juv\u00e9derm\u00ae Ultra XC<\/p>\n\n\n\n<p>Hylacross\u2122<br>Cohesivity score*: 4.1 at 95 secs<br>(mostly cohesive)<\/p>\n\n<\/div><\/div>\n<\/div>\n\n\n<figure class=\"wp-block-video bs-20u8Vf\"><video height=\"720\" style=\"aspect-ratio: 1280 \/ 720;\" width=\"1280\" controls poster=\"https:\/\/www.belotero.com\/app\/uploads\/2023\/10\/CompareVideo-FPO.jpg\" src=\"https:\/\/www.belotero.com\/app\/uploads\/2023\/11\/Belotero-JuvedermUltraXC.mp4\"><\/video><\/figure>\n\n<\/div><\/div>\n\n\n\n<div class=\"tab-pane fade\" id=\"bs-tabs-5Y9K1-2-pane\" role=\"tabpanel\" aria-labelledby=\"bs-tabs-5Y9K1-2-tab\"><div class=\"gb-container gb-container-d7ca5973\" id=\"ab-panel-3\">\n<div class=\"gb-grid-wrapper gb-grid-wrapper-db60c058\">\n<div class=\"gb-grid-column gb-grid-column-a0577145\"><div class=\"gb-container gb-container-a0577145\">\n\n<p class=\"gb-headline gb-headline-c66b1dae gb-headline-text\">Belotero Balance\u00ae<\/p>\n\n\n\n<p>Cohesive polydensified matrix<br>Cohesivity score*: 5.0<br>(fully cohesive)<\/p>\n\n<\/div><\/div>\n\n<div class=\"gb-grid-column gb-grid-column-dc127373\"><div class=\"gb-container gb-container-dc127373\">\n\n<p class=\"gb-headline gb-headline-dc99c13d gb-headline-text\">Juv\u00e9derm\u00ae Voluma\u00ae XC<\/p>\n\n\n\n<p>Vycross\u2122<br>Cohesivity score*: 1.3 at 95 secs<br>(mostly dispersed)<\/p>\n\n<\/div><\/div>\n<\/div>\n\n\n<figure class=\"wp-block-video bs-1uWGPg\"><video height=\"720\" style=\"aspect-ratio: 1280 \/ 720;\" width=\"1280\" controls src=\"https:\/\/www.belotero.com\/app\/uploads\/2023\/11\/Belotero-JuvedermVoluma.mp4\"><\/video><\/figure>\n\n<\/div><\/div>\n\n\n\n<div class=\"tab-pane fade\" id=\"bs-tabs-5Y9K1-3-pane\" role=\"tabpanel\" aria-labelledby=\"bs-tabs-5Y9K1-3-tab\"><div class=\"gb-container gb-container-7535a186\" id=\"ab-panel-4\">\n<div class=\"gb-grid-wrapper gb-grid-wrapper-35cb67f5\">\n<div class=\"gb-grid-column gb-grid-column-495bdd67\"><div class=\"gb-container gb-container-495bdd67\">\n\n<p class=\"gb-headline gb-headline-8dd57ed1 gb-headline-text\">Belotero Balance\u00ae<\/p>\n\n\n\n<p>Cohesive polydensified matrix<br>Cohesivity score*: 5.0<br>(fully cohesive)<\/p>\n\n<\/div><\/div>\n\n<div class=\"gb-grid-column gb-grid-column-20038f7b\"><div class=\"gb-container gb-container-20038f7b\">\n\n<p class=\"gb-headline gb-headline-fdd36a7c gb-headline-text\">RESTYLANE\u00ae<\/p>\n\n\n\n<p>Non\u2013animal stabilized<br>Cohesivity score*: 1.0 at 95 secs<br>(mostly dispersed)<\/p>\n\n<\/div><\/div>\n<\/div>\n\n\n<figure class=\"wp-block-video bs-2sbTfC\"><video height=\"720\" style=\"aspect-ratio: 1280 \/ 720;\" width=\"1280\" controls src=\"https:\/\/www.belotero.com\/app\/uploads\/2023\/11\/Belotero-Restylane.mp4\"><\/video><\/figure>\n\n<\/div><\/div>\n<\/div><\/div>\n\n\n\n<p class=\"gb-headline gb-headline-45aa05c8 gb-headline-text\">Evaluation of HA fillers with the Gavard-Sundaram Cohesivity Scale after extrusion<sup>11<\/sup><\/p>\n\n\n\n<figure class=\"gb-block-image gb-block-image-11c1aff4\"><img decoding=\"async\" class=\"gb-image gb-image-11c1aff4\" src=\"https:\/\/www.belotero.com\/app\/uploads\/2024\/01\/cohesivityChart-2.svg\" alt=\"bar chart of HA fillers evaluated by the Gavard-Sundaram Cohesivity Scale\" title=\"cohesivityChart-2\"\/><\/figure>\n\n\n\n<figure class=\"gb-block-image gb-block-image-fd94c1ba\"><img decoding=\"async\" class=\"gb-image gb-image-fd94c1ba\" src=\"https:\/\/www.belotero.com\/app\/uploads\/2024\/01\/cohesivityChart-mobile-2.svg\" alt=\"bar chart of HA fillers evaluated by the Gavard-Sundaram Cohesivity Scale\" title=\"cohesivityChart-mobile-2\"\/><\/figure>\n\n\n<div class=\"gb-container gb-container-ac9dbda1\">\n<div class=\"gb-container gb-container-352b832f\">\n\n<div data-wp-context=\"{ &quot;autoclose&quot;: false, &quot;accordionItems&quot;: [] }\" data-wp-interactive=\"core\/accordion\" role=\"group\" class=\"wp-block-accordion is-layout-flow wp-block-accordion-is-layout-flow\">\n<div data-wp-class--is-open=\"state.isOpen\" data-wp-context=\"{ &quot;id&quot;: &quot;accordion-item-2&quot;, &quot;openByDefault&quot;: false }\" data-wp-init=\"callbacks.initAccordionItems\" data-wp-on-window--hashchange=\"callbacks.hashChange\" class=\"wp-block-accordion-item is-layout-flow wp-block-accordion-item-is-layout-flow\">\n<h3 class=\"wp-block-accordion-heading has-small-font-size\"><button aria-expanded=\"false\" aria-controls=\"accordion-item-2-panel\" data-wp-bind--aria-expanded=\"state.isOpen\" data-wp-on--click=\"actions.toggle\" data-wp-on--keydown=\"actions.handleKeyDown\" id=\"accordion-item-2\" type=\"button\" class=\"wp-block-accordion-heading__toggle\"><span class=\"wp-block-accordion-heading__toggle-title\">Expand for Image Description<\/span><span class=\"wp-block-accordion-heading__toggle-icon\" aria-hidden=\"true\">+<\/span><\/button><\/h3>\n\n\n\n<div inert aria-labelledby=\"accordion-item-2\" data-wp-bind--inert=\"!state.isOpen\" id=\"accordion-item-2-panel\" role=\"region\" class=\"wp-block-accordion-panel is-layout-flow wp-block-accordion-panel-is-layout-flow\"><div class=\"gb-container gb-container-a7d59fdc\">\n\n<p>In an evaluation of HA fillers with the Gavard-Sundaram Cohesivity Scale after extrusion:<\/p>\n\n\n\n<figure class=\"wp-block-table is-style-regular\"><table class=\"has-fixed-layout\" style=\"border-width:1px\"><thead><tr><th>Product<\/th><th>Time points of analysis (seconds)<\/th><th>Cohesivity score<\/th><\/tr><\/thead><tbody><tr><td>Restylane Lyft<\/td><td>15<\/td><td>1<\/td><\/tr><tr><td><\/td><td>70<\/td><td>1<\/td><\/tr><tr><td><\/td><td>95<\/td><td>1<\/td><\/tr><tr><td>Restylane-L<\/td><td>15<\/td><td>2<\/td><\/tr><tr><td><\/td><td>70<\/td><td>1<\/td><\/tr><tr><td><\/td><td>95<\/td><td>1<\/td><\/tr><tr><td>Juv\u00e9derm Voluma<\/td><td>15<\/td><td>3<\/td><\/tr><tr><td><\/td><td>70<\/td><td>2<\/td><\/tr><tr><td><\/td><td>95<\/td><td>2<\/td><\/tr><tr><td>Juv\u00e9derm Volbella<\/td><td>15<\/td><td>3<\/td><\/tr><tr><td><\/td><td>70<\/td><td>2<\/td><\/tr><tr><td><\/td><td>95<\/td><td>2<\/td><\/tr><tr><td>Restylane Silk<\/td><td>15<\/td><td>5<\/td><\/tr><tr><td><\/td><td>70<\/td><td>3<\/td><\/tr><tr><td><\/td><td>95<\/td><td>3<\/td><\/tr><tr><td>Juv\u00e9derm Ultra Plus XC<\/td><td>15<\/td><td>5<\/td><\/tr><tr><td><\/td><td>70<\/td><td>4<\/td><\/tr><tr><td><\/td><td>95<\/td><td>4<\/td><\/tr><tr><td>Juv\u00e9derm Ultra XC<\/td><td>15<\/td><td>5<\/td><\/tr><tr><td><\/td><td>70<\/td><td>4<\/td><\/tr><tr><td><\/td><td>95<\/td><td>4<\/td><\/tr><tr><td>Belotero Balance<\/td><td>15<\/td><td>5<\/td><\/tr><tr><td><\/td><td>70<\/td><td>5<\/td><\/tr><tr><td><\/td><td>95<\/td><td>5<\/td><\/tr><\/tbody><\/table><\/figure>\n\n<\/div><\/div>\n<\/div>\n<\/div>\n\n<\/div>\n<\/div>\n\n\n<p class=\"gb-headline gb-headline-f4b45043 gb-headline-text small\">*No significant difference in cohesivity score before and after extrusion through a needle. Time points of analysis: 15, 70, and 95 seconds.<sup>10,11<\/sup><\/p>\n\n\n\n<h3 class=\"gb-headline gb-headline-b75f5e35 gb-headline-text\" id=\"elasticity\">Belotero Balance (+) has LOW elasticity<\/h3>\n\n\n\n<h4 class=\"gb-headline gb-headline-62505294 gb-headline-text\">Compare the elasticity of 8 HA fillers<\/h4>\n\n\n\n<p class=\"gb-headline gb-headline-096b0784 gb-headline-text\">Elastic modulus (G&#8217;) after needle extrusion* at testing frequency (0.7 Hz) after extrusion<sup>12<\/sup><\/p>\n\n\n\n<figure class=\"gb-block-image gb-block-image-42e35c4c\"><img decoding=\"async\" class=\"gb-image gb-image-42e35c4c\" src=\"https:\/\/www.belotero.com\/app\/uploads\/2024\/01\/elasticityChart-3.svg\" alt=\"Bar chart comparing the elasticity of 8 HA fillers\" title=\"elasticityChart-3\"\/><\/figure>\n\n\n\n<figure class=\"gb-block-image gb-block-image-8b964c02\"><img decoding=\"async\" class=\"gb-image gb-image-8b964c02\" src=\"https:\/\/www.belotero.com\/app\/uploads\/2024\/01\/elasticityChart-mobile-3.svg\" alt=\"Bar chart comparing the elasticity of 8 HA fillers\" title=\"elasticityChart-mobile-3\"\/><\/figure>\n\n\n<div class=\"gb-container gb-container-1b542a85\">\n<div class=\"gb-container gb-container-1739fb50\">\n\n<div data-wp-context=\"{ &quot;autoclose&quot;: false, &quot;accordionItems&quot;: [] }\" data-wp-interactive=\"core\/accordion\" role=\"group\" class=\"wp-block-accordion is-layout-flow wp-block-accordion-is-layout-flow\">\n<div data-wp-class--is-open=\"state.isOpen\" data-wp-context=\"{ &quot;id&quot;: &quot;accordion-item-3&quot;, &quot;openByDefault&quot;: false }\" data-wp-init=\"callbacks.initAccordionItems\" data-wp-on-window--hashchange=\"callbacks.hashChange\" class=\"wp-block-accordion-item is-layout-flow wp-block-accordion-item-is-layout-flow\">\n<h3 class=\"wp-block-accordion-heading has-small-font-size\"><button aria-expanded=\"false\" aria-controls=\"accordion-item-3-panel\" data-wp-bind--aria-expanded=\"state.isOpen\" data-wp-on--click=\"actions.toggle\" data-wp-on--keydown=\"actions.handleKeyDown\" id=\"accordion-item-3\" type=\"button\" class=\"wp-block-accordion-heading__toggle\"><span class=\"wp-block-accordion-heading__toggle-title\">Expand for Image Description<\/span><span class=\"wp-block-accordion-heading__toggle-icon\" aria-hidden=\"true\">+<\/span><\/button><\/h3>\n\n\n\n<div inert aria-labelledby=\"accordion-item-3\" data-wp-bind--inert=\"!state.isOpen\" id=\"accordion-item-3-panel\" role=\"region\" class=\"wp-block-accordion-panel is-layout-flow wp-block-accordion-panel-is-layout-flow\"><div class=\"gb-container gb-container-4546b66b\">\n\n<p>In an evaluation of HA fillers with the Gavard-Sundaram Cohesivity Scale:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>Product<\/th><th><strong>G&#8217; (0.7 Hz), Pa (measure of material stiffness)<\/strong><\/th><\/tr><\/thead><tbody><tr><td>Restylane Lyft<\/td><td>747<\/td><\/tr><tr><td>Restylane-L<\/td><td>732<\/td><\/tr><tr><td>Restylane Silk<\/td><td>517<\/td><\/tr><tr><td>Juv\u00e9derm Voluma<\/td><td>305<\/td><\/tr><tr><td>Juv\u00e9derm Volbella<\/td><td>213<\/td><\/tr><tr><td>Juv\u00e9derm Ultra Plus XC<\/td><td>146<\/td><\/tr><tr><td>Juv\u00e9derm Ultra XC<\/td><td>110<\/td><\/tr><tr><td>Belotero Balance<\/td><td>41<\/td><\/tr><\/tbody><\/table><\/figure>\n\n<\/div><\/div>\n<\/div>\n<\/div>\n\n<\/div>\n<\/div>\n\n\n<p class=\"gb-headline gb-headline-e7931e7d gb-headline-text small\">*No significant difference in cohesivity score before and after extrusion through a needle.<\/p>\n\n\n\n<h3 class=\"gb-headline gb-headline-b45562b6 gb-headline-text\" id=\"viscosity\">Belotero Balance (+) has LOW viscosity<\/h3>\n\n\n\n<h4 class=\"gb-headline gb-headline-3721f59e gb-headline-text\">Compare the viscosity of 8 HA fillers<\/h4>\n\n\n\n<p class=\"gb-headline gb-headline-584ced8e gb-headline-text\">Complex viscosity (\u03b7*) after needle extrusion* at testing frequency (0.7 Hz) after extrusion<sup>12<\/sup><\/p>\n\n\n\n<figure class=\"gb-block-image gb-block-image-29758177\"><img decoding=\"async\" class=\"gb-image gb-image-29758177\" src=\"https:\/\/www.belotero.com\/app\/uploads\/2024\/01\/viscosityChart-3.svg\" alt=\"Bar chart comparing the viscosity of 8 HA fillers\" title=\"viscosityChart-3\"\/><\/figure>\n\n\n\n<figure class=\"gb-block-image gb-block-image-d0c574ce\"><img decoding=\"async\" class=\"gb-image gb-image-d0c574ce\" src=\"https:\/\/www.belotero.com\/app\/uploads\/2024\/01\/viscosityChart-mobile-2.svg\" alt=\"Bar chart comparing the viscosity of 8 HA fillers\" title=\"viscosityChart-mobile-2\"\/><\/figure>\n\n\n<div class=\"gb-container gb-container-93b91854\">\n<div class=\"gb-container gb-container-6e558699\">\n\n<div data-wp-context=\"{ &quot;autoclose&quot;: false, &quot;accordionItems&quot;: [] }\" data-wp-interactive=\"core\/accordion\" role=\"group\" class=\"wp-block-accordion is-layout-flow wp-block-accordion-is-layout-flow\">\n<div data-wp-class--is-open=\"state.isOpen\" data-wp-context=\"{ &quot;id&quot;: &quot;accordion-item-4&quot;, &quot;openByDefault&quot;: false }\" data-wp-init=\"callbacks.initAccordionItems\" data-wp-on-window--hashchange=\"callbacks.hashChange\" class=\"wp-block-accordion-item is-layout-flow wp-block-accordion-item-is-layout-flow\">\n<h3 class=\"wp-block-accordion-heading has-small-font-size\"><button aria-expanded=\"false\" aria-controls=\"accordion-item-4-panel\" data-wp-bind--aria-expanded=\"state.isOpen\" data-wp-on--click=\"actions.toggle\" data-wp-on--keydown=\"actions.handleKeyDown\" id=\"accordion-item-4\" type=\"button\" class=\"wp-block-accordion-heading__toggle\"><span class=\"wp-block-accordion-heading__toggle-title\">Expand for Image Description<\/span><span class=\"wp-block-accordion-heading__toggle-icon\" aria-hidden=\"true\">+<\/span><\/button><\/h3>\n\n\n\n<div inert aria-labelledby=\"accordion-item-4\" data-wp-bind--inert=\"!state.isOpen\" id=\"accordion-item-4-panel\" role=\"region\" class=\"wp-block-accordion-panel is-layout-flow wp-block-accordion-panel-is-layout-flow\"><div class=\"gb-container gb-container-1cb1329d\">\n\n<p>In an evaluation of HA fillers with the Gavard-Sundaram Cohesivity Scale:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>Product<\/th><th><strong>\u03b7* (0.7 Hz), Pa.s (measure of ability to spread)<\/strong><\/th><\/tr><\/thead><tbody><tr><td>Restylane Lyft<\/td><td>191<\/td><\/tr><tr><td>Restylane-L<\/td><td>188<\/td><\/tr><tr><td>Restylane Silk<\/td><td>136<\/td><\/tr><tr><td>Juv\u00e9derm Voluma<\/td><td>77<\/td><\/tr><tr><td>Juv\u00e9derm Volbella<\/td><td>54<\/td><\/tr><tr><td>Juv\u00e9derm Ultra Plus XC<\/td><td>38<\/td><\/tr><tr><td>Juv\u00e9derm Ultra XC<\/td><td>29<\/td><\/tr><tr><td>Belotero Balance<\/td><td>10<\/td><\/tr><\/tbody><\/table><\/figure>\n\n<\/div><\/div>\n<\/div>\n<\/div>\n\n<\/div>\n<\/div>\n\n\n<p class=\"gb-headline gb-headline-a11f0309 gb-headline-text small\">*No significant difference in viscosity score before and after extrusion through a needle.<\/p>\n\n<\/div><\/div>\n<\/div>\n<\/div>\n<\/section>\n\n<section class=\"gb-container gb-container-e22a365b section-hcp section-hcp--body\">\n<div class=\"gb-container gb-container-e271b445 grid-container\">\n\n<h2 class=\"gb-headline gb-headline-4b6b1750 gb-headline-text\" id=\"tissue-integration\">CROSS-LINKING TECHNOLOGY SUPPORTS OPTIMAL TISSUE INTEGRATION<\/h2>\n\n\n<div class=\"gb-grid-wrapper gb-grid-wrapper-89bce3e8\">\n<div class=\"gb-grid-column gb-grid-column-ed7410f8\"><div class=\"gb-container gb-container-ed7410f8\">\n\n<figure class=\"wp-block-video\"><video controls src=\"https:\/\/www.belotero.com\/app\/uploads\/2023\/11\/crossLInk-1.mp4\"><\/video><\/figure>\n\n\n<div class=\"gb-container gb-container-c1e68bd4\">\n<div class=\"gb-container gb-container-46da43d4\">\n\n<div data-wp-context=\"{ &quot;autoclose&quot;: false, &quot;accordionItems&quot;: [] }\" data-wp-interactive=\"core\/accordion\" role=\"group\" id=\"gb-accordion__toggle\" class=\"wp-block-accordion is-layout-flow wp-block-accordion-is-layout-flow\">\n<div data-wp-class--is-open=\"state.isOpen\" data-wp-context=\"{ &quot;id&quot;: &quot;accordion-item-5&quot;, &quot;openByDefault&quot;: false }\" data-wp-init=\"callbacks.initAccordionItems\" data-wp-on-window--hashchange=\"callbacks.hashChange\" class=\"wp-block-accordion-item is-layout-flow wp-block-accordion-item-is-layout-flow\">\n<h3 class=\"wp-block-accordion-heading has-small-font-size\"><button aria-expanded=\"false\" aria-controls=\"accordion-item-5-panel\" data-wp-bind--aria-expanded=\"state.isOpen\" data-wp-on--click=\"actions.toggle\" data-wp-on--keydown=\"actions.handleKeyDown\" id=\"accordion-item-5\" type=\"button\" class=\"wp-block-accordion-heading__toggle\"><span class=\"wp-block-accordion-heading__toggle-title\">Expand for Transcript<\/span><span class=\"wp-block-accordion-heading__toggle-icon\" aria-hidden=\"true\">+<\/span><\/button><\/h3>\n\n\n\n<div inert aria-labelledby=\"accordion-item-5\" data-wp-bind--inert=\"!state.isOpen\" id=\"accordion-item-5-panel\" role=\"region\" class=\"wp-block-accordion-panel is-layout-flow wp-block-accordion-panel-is-layout-flow\"><div class=\"gb-container gb-container-c562a4e8\">\n<div class=\"gb-grid-wrapper gb-grid-wrapper-edfedd74\">\n<div class=\"gb-grid-column gb-grid-column-5ba98b4f\"><div class=\"gb-container gb-container-5ba98b4f\">\n\n<p>PHASE 1<br>HA in its original form<br>(single chains, random coil structure)<sup>1<\/sup><\/p>\n\n<\/div><\/div>\n\n<div class=\"gb-grid-column gb-grid-column-cbb73c34\"><div class=\"gb-container gb-container-cbb73c34\">\n\n<p>PHASE 2<br>Linearization of the individual HA<br>chains; the random coil structure<br>untangles<sup>1<\/sup><\/p>\n\n<\/div><\/div>\n\n<div class=\"gb-grid-column gb-grid-column-e14b5de6\"><div class=\"gb-container gb-container-e14b5de6\">\n\n<p>PHASE 3<br>First HA cross-linking process<br>with butanediol diglycidyl ether (BDDE);<br>a cellular, monophasic gel emerges<sup>1<\/sup><\/p>\n\n<\/div><\/div>\n\n<div class=\"gb-grid-column gb-grid-column-c6f38342\"><div class=\"gb-container gb-container-c6f38342\">\n\n<p>PHASE 4<br>Expansion of the gel that was created<br>in the cross-linking process<sup>14<\/sup><\/p>\n\n<\/div><\/div>\n\n<div class=\"gb-grid-column gb-grid-column-68952f92\"><div class=\"gb-container gb-container-68952f92\">\n\n<p>PHASE 5<br>A second application of HA<br>links the residual BDDE to the fibers; the gel results in a cohesive polydensified<br>matrix<sup>14<\/sup><\/p>\n\n<\/div><\/div>\n<\/div>\n<\/div><\/div>\n<\/div>\n<\/div>\n\n<\/div>\n<\/div>\n<\/div><\/div>\n\n<div class=\"gb-grid-column gb-grid-column-7c0a8ceb\"><div class=\"gb-container gb-container-7c0a8ceb\">\n\n<p>Different cross-linking technologies and the degree and type of cross-linking result in HA dermal fillers with various rheologic profiles and unique biophysical characteristics. <\/p>\n\n\n\n<p>Belotero Balance (+) is manufactured to have different proportions of HA cross-linking density to provide the cohesivity required for seamless, natural tissue integration in harmony with facial movements.<sup>13<\/sup>&nbsp; Additionally, the dynamic cross-linking manufacturing processes of Belotero Balance (+) create<sup>1<\/sup>:<\/p>\n\n\n\n<ul style=\"font-style:normal;font-weight:300\" class=\"wp-block-list\">\n<li>A cohesive and homogeneous gel<\/li>\n\n\n\n<li>Zones of greater or lesser cross-linking density<\/li>\n\n\n\n<li>Low elasticity and viscosity and high tan delta<\/li>\n<\/ul>\n\n<\/div><\/div>\n<\/div>\n<\/div>\n\n<div class=\"gb-container gb-container-d425ae79 grid-container\">\n<div class=\"gb-grid-wrapper gb-grid-wrapper-3ac47a84\">\n<div class=\"gb-grid-column gb-grid-column-b9fd74b7\"><div class=\"gb-container gb-container-b9fd74b7\">\n\n<h3 class=\"gb-headline gb-headline-8a9453a4 gb-headline-text\">Compare Belotero Balance (+) tissue integration with other HA fillers<\/h3>\n\n\n\n<p style=\"margin-bottom:40px\">Belotero Balance (+) demonstrates a homogenous pattern of distribution and optimal tissue integration<sup>3,5<\/sup><\/p>\n\n\n<div class=\"gb-container gb-container-212a0084\">\n\n<figure class=\"gb-block-image gb-block-image-42fbbca7\"><img data-recalc-dims=\"1\" decoding=\"async\" class=\"gb-image gb-image-42fbbca7\" src=\"https:\/\/i0.wp.com\/www.belotero.com\/app\/uploads\/2023\/10\/tissueIntegration-mobile.webp?ssl=1\" alt=\"Van Gieson elastin staining comparison after 8 days of control, Belotero Balance, Juv\u00e9derm Ultra XC, and Restylane\" title=\"tissueIntegration-mobile\"\/><\/figure>\n\n\n\n<figure class=\"gb-block-image gb-block-image-2e3334fc\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" width=\"695\" height=\"495\" class=\"gb-image gb-image-2e3334fc\" src=\"https:\/\/i0.wp.com\/www.belotero.com\/app\/uploads\/2023\/10\/tissueIntegration.webp?resize=695%2C495&#038;ssl=1\" alt=\"Van Gieson elastin staining comparison after 8 days of control, Belotero Balance, Juv\u00e9derm Ultra XC, and Restylane\" title=\"tissueIntegration\" srcset=\"https:\/\/i0.wp.com\/merzaesthetics-ca.m3rzd3v.com\/app\/uploads\/2023\/10\/tissueIntegration.webp?w=695&amp;ssl=1 695w, https:\/\/i0.wp.com\/merzaesthetics-ca.m3rzd3v.com\/app\/uploads\/2023\/10\/tissueIntegration.webp?resize=300%2C214&amp;ssl=1 300w\" sizes=\"auto, (max-width: 695px) 100vw, 695px\" \/><\/figure>\n\n\n\n<p class=\"small\" style=\"padding-top:10px\">Adapted from Tran C, et al. <em>Dermatology<\/em>. 2014;228(1):47-54.<\/p>\n\n\n<div class=\"gb-container gb-container-c6bf221a\">\n<div class=\"gb-container gb-container-c55d52f0\">\n\n<div data-wp-context=\"{ &quot;autoclose&quot;: false, &quot;accordionItems&quot;: [] }\" data-wp-interactive=\"core\/accordion\" role=\"group\" class=\"wp-block-accordion is-layout-flow wp-block-accordion-is-layout-flow\">\n<div data-wp-class--is-open=\"state.isOpen\" data-wp-context=\"{ &quot;id&quot;: &quot;accordion-item-6&quot;, &quot;openByDefault&quot;: false }\" data-wp-init=\"callbacks.initAccordionItems\" data-wp-on-window--hashchange=\"callbacks.hashChange\" class=\"wp-block-accordion-item is-layout-flow wp-block-accordion-item-is-layout-flow\">\n<h3 class=\"wp-block-accordion-heading has-small-font-size\"><button aria-expanded=\"false\" aria-controls=\"accordion-item-6-panel\" data-wp-bind--aria-expanded=\"state.isOpen\" data-wp-on--click=\"actions.toggle\" data-wp-on--keydown=\"actions.handleKeyDown\" id=\"accordion-item-6\" type=\"button\" class=\"wp-block-accordion-heading__toggle\"><span class=\"wp-block-accordion-heading__toggle-title\">Expand for Image Description<\/span><span class=\"wp-block-accordion-heading__toggle-icon\" aria-hidden=\"true\">+<\/span><\/button><\/h3>\n\n\n\n<div inert aria-labelledby=\"accordion-item-6\" data-wp-bind--inert=\"!state.isOpen\" id=\"accordion-item-6-panel\" role=\"region\" class=\"wp-block-accordion-panel is-layout-flow wp-block-accordion-panel-is-layout-flow\"><div class=\"gb-container gb-container-4610ea9c\">\n\n<p>Van Gieson elastin staining comparison after 8 days of control, Belotero Balance, Juv\u00e9derm Ultra XC, and Restylane, demonstrating more homogenous tissue integration with Belotero Balance (+).<sup>3<\/sup><\/p>\n\n<\/div><\/div>\n<\/div>\n<\/div>\n\n<\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n<\/div>\n<\/div>\n<\/section>\n\n<section class=\"gb-container gb-container-2b17e2eb section-hcp section-hcp--body\">\n<div class=\"gb-container gb-container-607cf77c grid-container\">\n<div class=\"gb-container gb-container-d19ef813\">\n\n<h2 class=\"gb-headline gb-headline-0e9dc7db gb-headline-text\" id=\"duration\">CLINICAL TRIAL RESULTS SUPPORT BELOTERO BALANCE (+) EFFICACY AND DURATION<\/h2>\n\n\n\n<p style=\"margin-bottom:40px\">Belotero Balance (+) has been evaluated in a long-term clinical study in patients treated with Belotero Balance (+) in one nasolabial fold (NLF) and bovine collagen in the other NLF.<sup>7<\/sup><\/p>\n\n<\/div>\n\n<div class=\"gb-grid-wrapper gb-grid-wrapper-56295853\">\n<div class=\"gb-grid-column gb-grid-column-0136986f\"><div class=\"gb-container gb-container-0136986f\">\n\n<h3 class=\"gb-headline gb-headline-2f4bcb65 gb-headline-text\">Results last 6 months or longer<sup>7,15<\/sup><\/h3>\n\n\n\n<ul style=\"font-style:normal;font-weight:300\" class=\"wp-block-list\">\n<li>Primary endpoint: Mean change from baseline score of each NLF 12 weeks after last injection<\/li>\n\n\n\n<li>Belotero Balance (+) showed a significantly greater reduction in NLF compared to bovine collagen at weeks 8 (<em>P<\/em>=0.009), 12 (<em>P<\/em>&lt;0.001), and 24 (<em>P<\/em>&lt;0.001)\n<ul class=\"wp-block-list\">\n<li>A majority of patients did not need a repeat injection for at least 48 weeks<sup>15<\/sup><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n<div class=\"gb-container gb-container-2a0d6ab6\">\n<div class=\"gb-container gb-container-13df7e5e\">\n\n<div data-wp-context=\"{ &quot;autoclose&quot;: false, &quot;accordionItems&quot;: [] }\" data-wp-interactive=\"core\/accordion\" role=\"group\" class=\"wp-block-accordion is-layout-flow wp-block-accordion-is-layout-flow\">\n<div data-wp-class--is-open=\"state.isOpen\" data-wp-context=\"{ &quot;id&quot;: &quot;accordion-item-7&quot;, &quot;openByDefault&quot;: false }\" data-wp-init=\"callbacks.initAccordionItems\" data-wp-on-window--hashchange=\"callbacks.hashChange\" class=\"wp-block-accordion-item is-layout-flow wp-block-accordion-item-is-layout-flow\">\n<h3 class=\"wp-block-accordion-heading has-small-font-size\"><button aria-expanded=\"false\" aria-controls=\"accordion-item-7-panel\" data-wp-bind--aria-expanded=\"state.isOpen\" data-wp-on--click=\"actions.toggle\" data-wp-on--keydown=\"actions.handleKeyDown\" id=\"accordion-item-7\" type=\"button\" class=\"wp-block-accordion-heading__toggle\"><span class=\"wp-block-accordion-heading__toggle-title\">Expand for study details<\/span><span class=\"wp-block-accordion-heading__toggle-icon\" aria-hidden=\"true\">+<\/span><\/button><\/h3>\n\n\n\n<div inert aria-labelledby=\"accordion-item-7\" data-wp-bind--inert=\"!state.isOpen\" id=\"accordion-item-7-panel\" role=\"region\" class=\"wp-block-accordion-panel is-layout-flow wp-block-accordion-panel-is-layout-flow\"><div class=\"gb-container gb-container-2a8b7be4\">\n\n<p><strong>Additional study details<\/strong><sup><strong>7,15<\/strong><\/sup><\/p>\n\n\n\n<ul style=\"font-style:normal;font-weight:300\" class=\"wp-block-list\">\n<li>All patients were given Belotero Balance in one NLF and bovine collagen in the<br>other NLF<\/li>\n\n\n\n<li>There was an option for touch-up at 2 weeks<\/li>\n\n\n\n<li>Patients returned every 2 weeks through 24 weeks for evaluation<\/li>\n\n\n\n<li>Results were as assessed by both the treating physician and blinded evaluator on the Wrinkle Severity Rating Scale<\/li>\n\n\n\n<li>Open-label extension allowed for treatment of Belotero Balance (+) in both NLFs that lasted from 24 to 96 weeks after the initial visit. A touch-up was allowed at 32 weeks<\/li>\n<\/ul>\n\n<\/div><\/div>\n<\/div>\n<\/div>\n\n<\/div>\n<\/div>\n<\/div><\/div>\n\n<div class=\"gb-grid-column gb-grid-column-5f72ef7c\"><div class=\"gb-container gb-container-5f72ef7c\">\n\n<h4 class=\"gb-headline gb-headline-f78a5227 gb-headline-text\">Mean Change from baseline of Wrinkle Severity Rating Scale at Week 24<sup>15<\/sup><\/h4>\n\n\n\n<figure class=\"gb-block-image gb-block-image-9cae6eaf\"><img decoding=\"async\" class=\"gb-image gb-image-9cae6eaf\" src=\"https:\/\/www.belotero.com\/app\/uploads\/2024\/01\/meanChart-2.svg\" alt=\"Mean change from baseline in nasolabial fold wrinkle reduction for the treating physician and blinded evaluator\" title=\"meanChart-2\"\/><\/figure>\n\n\n\n<figure class=\"gb-block-image gb-block-image-8b19ef4d\"><img decoding=\"async\" class=\"gb-image gb-image-8b19ef4d\" src=\"https:\/\/www.belotero.com\/app\/uploads\/2024\/01\/meanChart-mobile-2.svg\" alt=\"Mean change from baseline in nasolabial fold wrinkle reduction for the treating physician and blinded evaluator\" title=\"meanChart-mobile-2\"\/><\/figure>\n\n\n<div class=\"gb-container gb-container-22ab5eae\">\n<div class=\"gb-container gb-container-93e3b25f\">\n\n<div data-wp-context=\"{ &quot;autoclose&quot;: false, &quot;accordionItems&quot;: [] }\" data-wp-interactive=\"core\/accordion\" role=\"group\" class=\"wp-block-accordion is-layout-flow wp-block-accordion-is-layout-flow\">\n<div data-wp-class--is-open=\"state.isOpen\" data-wp-context=\"{ &quot;id&quot;: &quot;accordion-item-8&quot;, &quot;openByDefault&quot;: false }\" data-wp-init=\"callbacks.initAccordionItems\" data-wp-on-window--hashchange=\"callbacks.hashChange\" class=\"wp-block-accordion-item is-layout-flow wp-block-accordion-item-is-layout-flow\">\n<h3 class=\"wp-block-accordion-heading has-small-font-size\"><button aria-expanded=\"false\" aria-controls=\"accordion-item-8-panel\" data-wp-bind--aria-expanded=\"state.isOpen\" data-wp-on--click=\"actions.toggle\" data-wp-on--keydown=\"actions.handleKeyDown\" id=\"accordion-item-8\" type=\"button\" class=\"wp-block-accordion-heading__toggle\"><span class=\"wp-block-accordion-heading__toggle-title\">Expand for Image Description<\/span><span class=\"wp-block-accordion-heading__toggle-icon\" aria-hidden=\"true\">+<\/span><\/button><\/h3>\n\n\n\n<div inert aria-labelledby=\"accordion-item-8\" data-wp-bind--inert=\"!state.isOpen\" id=\"accordion-item-8-panel\" role=\"region\" class=\"wp-block-accordion-panel is-layout-flow wp-block-accordion-panel-is-layout-flow\"><div class=\"gb-container gb-container-137115c4\">\n\n<p><strong>Mean change from baseline of Wrinkle Severity Rating Scale:<\/strong><br><strong>Treating physician:<\/strong> 1.23 vs 0.49 [Belotero Balance (+) vs bovine collagen; <em>P<\/em>&lt;0.001]<br><strong>Blinded evaluator:<\/strong> 1.08 vs 0.5 [Belotero Balance (+) vs bovine collagen; <em>P<\/em>&lt;0.001]<\/p>\n\n<\/div><\/div>\n<\/div>\n<\/div>\n\n<\/div>\n<\/div>\n<\/div><\/div>\n<\/div>\n<\/div>\n<\/section>\n\n<section class=\"gb-container gb-container-100b868e section-hcp section-hcp--cta\">\n<div class=\"gb-container gb-container-b7158a51 grid-container\">\n<div class=\"gb-grid-wrapper gb-grid-wrapper-c9eaaec3\">\n<div class=\"gb-grid-column gb-grid-column-6fa0f154\"><div class=\"gb-container gb-container-6fa0f154 splotch-element\">\n\n<h2 class=\"gb-headline gb-headline-52a20b02 gb-headline-text\">LEARN MORE ABOUT HOW TO USE BELOTERO BALANCE (+)<\/h2>\n\n\n\n<p style=\"margin-bottom:20px\">Belotero Balance (+) may be an ideal option for patients who want to address moderate to severe etched-in lines and wrinkles, who are new to fillers, or who want an alternative to laser treatments and chemical peels. Learn more about treatment areas, and see before-&amp;-after images of real patients treated with Belotero Balance (+).<\/p>\n\n\n\n<a class=\"gb-button gb-button-dbe4595b gb-button-text gb-button-acf94e91\" href=\"\/belotero\/hcp\/belotero-treatment-areas\/\">See Treatment Areas<\/a>\n\n<\/div><\/div>\n<\/div>\n<\/div>\n<\/section>\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>AN HA FILLER DESIGNED TO FLEX Rheologic properties\u2014such as cohesivity, elasticity, and viscosity\u2014are used as a scientific rationale when selecting the appropriate filler for specific clinical applications. Learn more about the clinical significance of these properties, and then understand how the rheologic profile of Belotero Balance (+) contributes to its ability to achieve results with [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":0,"parent":0,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"custom-page-category":[],"class_list":["post-159","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<title>Clinical Data &amp; MOA | Belotero Balance\u00ae (+) HCP<\/title>\n<meta name=\"description\" content=\"See clinical data and MOA information on Belotero Balance (+) a hyalauronic acid filler. 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